氯丙嗪、尼莫地平单用和合用对小鼠镉中毒肝、肾毒效应的影响

doi:10.3969/j.issn.1004-616x.1999.06.016

癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (6): 334-337.doi: 10.3969/j.issn.1004-616x.1999.06.016

氯丙嗪、尼莫地平单用和合用对小鼠镉中毒肝、肾毒效应的影响

唐玲芳　陈砚朦　张珍玲　宋　玲　杨永年　冯致英

南京医科大学　卫生毒理学教研室　南京　210029

收稿日期:1999-07-26 修回日期:1999-07-26 出版日期:1999-11-30 发布日期:1999-11-30

INFLUENCES OF CHLOROPAZINE, NIMODIPINE AND THEIR COMBINATON ON THE TOXIC EFFECTS OF CADMIUM ON LIVERS AND KIDNEYS OF MICE

Tang lingfang , Chen Yanmeg , Zhang Zhenling , Songling , Yang Yongnian , Feng Zhiying

Department of Toxicology , Nanjing Medical University , Nanjing 210029

Received:1999-07-26 Revised:1999-07-26 Online:1999-11-30 Published:1999-11-30

摘要/Abstract

摘要： 摘要　观察钙调素拮抗剂氯丙嗪(CPZ) 和钙离子通道阻断剂尼莫地平(NIMO) 以及同时给予以上两药对镉(Cd) 致小鼠肝、肾毒作用的保护作用。利用模拟镉中毒动物模型。实验组预先灌胃给予小鼠CPZ、NIMO、CPZ + NIMO ,1 小时后以1/ 5LD- 50CdCl2 腹腔注射,连续五天,第六天收集生物样本检测各项指标。结果表明,CPZ 能明显降低血镉,降低尿中r - GT 及NAG活性。CPZ 和NIMO 对于镉引起的钙泵活性降低,均表现出明显的保护作用,两药合用作用增强。CPZ 和NIMO 均能显著提高镉中毒小鼠肝、肾组织中镉金属硫蛋白(MT) 含量。揭示这两种钙拮抗剂对小鼠镉中毒肝、肾毒效应均有防护作用。CPZ 比NIMO 明显。这两种药物合用在某些方面起协同作用。该两药的防护作用可能与MT 参与有关。

关键词: 关键词　镉中毒, 氯丙嗪, 尼莫地平, 镉金属硫蛋白

Abstract: Abstract 　The influences of calmodulin antagonist CPZ , and calcium channel blocker NIMO and the combination on cadmiumpoisoning of mice were studied. Animal models for cadmiumpoisoning were established by peritoneal injection of 1/ 5 LD50CdCl2 , The experimental groups were protected by administering of CPZ、NIMO and combination of CPZ and NIMO respectively one hour before the injection of CdCl2 . Five consecutive days later , samples were collected for analysis. The data showed that the Cd content in blood and the urinaryγ2GT and NAG activities were reduced significantly by CPZ. Both CPZ and NIMO showed considerable protective effect against the decrease of Ca2 + - Mg2 + - ATPase activity , and a remarkable synergistic action between them was observed. Both CPZ and NIMO could considerably increase MT contents in livers and kidneys of Cd poisonig mice. The results indicated that the inhibitors could protect mice against the toxic effects of Cd on liver and kidney , while CPZ was more efficient than NIMO. The combination of CPZ and NIMO could exert a synergistic action in some aspects. The protective action of these two drugs might be relevent to the function of MT.

Key words: Key words 　Cadmium poisoning, Chloropazine (CPZ), Nimodipine (NIMO), Cadmiummetallothionein(Cd - MT)

唐玲芳　陈砚朦　张珍玲　宋　玲　杨永年　冯致英. 氯丙嗪、尼莫地平单用和合用对小鼠镉中毒肝、肾毒效应的影响[J]. 癌变·畸变·突变, 1999, 11(6): 334-337.

Tang lingfang , Chen Yanmeg , Zhang Zhenling , Songling , Yang Yongnian , Feng Zhiying. INFLUENCES OF CHLOROPAZINE, NIMODIPINE AND THEIR COMBINATON ON THE TOXIC EFFECTS OF CADMIUM ON LIVERS AND KIDNEYS OF MICE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(6): 334-337.

氯丙嗪、尼莫地平单用和合用对小鼠镉中毒肝、肾毒效应的影响

INFLUENCES OF CHLOROPAZINE, NIMODIPINE AND THEIR COMBINATON ON THE TOXIC EFFECTS OF CADMIUM ON LIVERS AND KIDNEYS OF MICE

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